Researchers are Trying to Get Cannabinoids Without Cannabis

Cannabis-producing drugs has long been outlawed, and therefore the interest of scientists. That is changing. Science is investigating how suitable substances can be obtained from it without the need to grow plants. 

Cannabis has been used for millennia not only as a drug but also as a medicine. Modern medicine returns to it. In many countries, medical cannabis use has already been legalized. Pharmaceutical companies are testing cannabis substances, collectively referred to as cannabinoids. 

They pay great attention to delta-9-tetrahydrocannabinol or THC, the primary molecule responsible for the narcotic effects of cannabis. However, cannabidiol (abbreviated CBD), which is not a narcotic, is not of interest either.

For example, a balanced mixture of pure THC and CBD has recently been shown to relieve patients of muscle cramps associated with certain neurodegenerative diseases. Pure CBD, in turn, suppresses seizures in some mental illnesses. This is different from “crude” THC-containing marijuana, the consumption of which increases the risk of such seizures.

Cannabis is the source of many dozens of exciting molecules in this plant only in trace amounts and whose effect on the human body is known very little. The lack of information on cannabis and cannabinoids is partly due to bans on growing varieties with a higher drug content.

Success in gene transfer

But even here, there is a noticeable turnaround. It was significantly helped by reading the complete hereditary information of three types of cannabis. In addition to marijuana cannabis with a high THC content, the researchers read the genome of the Finola variety, intended primarily for the production of oilseeds and DNA of the USO 31 variety, which contains few cannabinoids and is grown for textile fibers. 

Growing cannabis for THC and other cannabinoids is inefficient. In the plant, these substances occur preferentially in fine hairs or trichomes growing on the surface of leaves and flowers.

The vast majority of plant matter contains minimal THC and related molecules. However, hemp is the only known plant that produces THC, so its cultivation is widespread worldwide. Regarding the volume of illegal cannabis production, the UN Office on Drugs and Crime acknowledges that “the extent and trends in cannabis cultivation and marijuana and hashish production are difficult to estimate.” Cannabis cultivation has long been illegal. 

Many local varieties were destroyed in the fight against drugs. Illegal growers have focused primarily on plants producing high levels of THC and then vegetatively propagated.

Cannabis grown in different parts of the world is largely genetically identical today, and plants can be considered clones. These are why scientists are trying to get cannabinoids for treatment without the need to grow cannabis. 

A team led by Jay Keasling of the University of California, Berkeley recently reported in the scientific journal Nature the success of transferring the genes needed to synthesize cannabinoids from cannabis to yeast. Yeast grown in bioreactors then produce not only THC and CBD, but also other interesting substances.

Yeast can process molecules that do not have cannabis as a raw material and turn them into new types of cannabinoids that no terrestrial plant can produce. 

Researchers hope that at least some of these substances will be used in the treatment of serious diseases. Other research teams have successfully transferred the genes for the “production line” for cannabinoids to the hereditary information of bacteria or algae.

Biotechnological methods of cannabinoid production promise, among other things, a sharp reduction in producer prices. While a kilo of pure THC isolated from cannabis sells for more than five thousand dollars, the price of THC and other cannabinoids produced by yeast should fall below one thousand dollars per kilo.

Suppression of appetite

Scientists did not betray even cannabis. Many teams try to ensure that cannabinoids are not formed only in trichomes but are produced in bulk by the whole plant. Genetically modified cannabis has enzymes that reduce the toxicity of cannabinoids to patients while maintaining all the positive effects. 

Other genetic modifications turn cannabinoids into cannabis so that oils do not have to be used to dissolve them and ordinary water is enough. Such cannabinoids can be easily added to beverages and other foods. Because they are tasteless and odorless, consumers should not be particularly bothered.

Cannabis growers have previously tried to breed varieties with an enormously increased content of cannabinoids occurring in traditional types only in trace amounts. It was always a long-distance run with an extremely uncertain outcome. 

Genetic engineering methods can relatively easily achieve, for example, high production of tetrahydrocannabivarin in cannabis, which is known to suppress appetite and would find application in people struggling with obesity. Food and drinks with this cannabinoid would be rich and one would eat and drink less.

Other genetically modified lines of cannabis have been used to block genes necessary for THC synthesis. 

These plants then produce large amounts of CBD. By blocking another gene, the researchers obtained cannabis, in which the production of cannabinoids in the cannabigerol molecule ends. It protects the plant’s cells from being damaged by a number of adverse external influences. Pharmacists have high hopes for the treatment of various inflammatory diseases in this substance.

Until recently, the neglected research of cannabinoids turned into the Klondike engulfed in a “gold rush”. Courts are already settling the first patent disputes for cannabis and cannabinoids. 

The key is how much the patent is new. Because until recently, the production of cannabis was outlawed and the news was kept secret, it is often difficult for the courts to decide what is a revolutionary innovation and what is a “worn-out vest” pulled into the light of day from deep illegality.

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6 Ways to Use Cannabis Without Smoking

The most common way people use cannabis for millennia is to inhale smoke from pipes or cigarettes called joints. Today, however, we know that smoking is very harmful to health, and the burning of any plant material – including cannabis – and its subsequent inhalation into the lungs certainly does not benefit us.

Plus, not everyone likes to smoke. And someone may not even have a medical condition if they have lung problems. The idea of ​​smoking can discourage many people (especially the elderly who want to be treated with cannabis) from trying cannabis. Even in states where this plant is fully legal.

If you are also a fan of marijuana, then you will surely remember how you used it for the first time. Most likely, your first experience with marijuana was in the form of wrapped dried flowers in paper in the form of a so-called joint. Because marijuana has never been a cheap affair, it’s very likely that you also mixed your first cannabis cigarette with tobacco. 

Tobacco in combination with cannabis often changes the condition you experience after smoking. However, times have advanced today and many users are asking how to use cannabis if they want to avoid harmful smoking . At the same time, choosing the right method of use is key to achieving the results you want.

Despite the health risks associated with smoking or burning plant material, this form of use remains one of the most popular . This is probably due to the fact that the marijuana is immediately ready for use and the cost of packing the joint is an investment in the order of a few pennies, if we omit the purchase price of marijuana itself.

Fortunately, today there are many ways to take the benefits of cannabis without smoking, which are definitely healthier than smoking alone. Here in this article, we have prepared six ways for you to use marijuana without smoking.


As is known today, you can use marijuana without the heat from a lighter, because substances such as THC, CBD and others are actually released at much lower temperatures, starting at 170 ° C. The taste of the evaporated marijuana from the vaporizer, unlike smoke, has a pure taste and the steam is much softer and with the aggressiveness of the smoke it really cannot be compared. 

There are plenty of vaporizers on the market today, as marijuana and other herbs are called. Large desktop vaporizers provide you with quality steam with the ability to set accurate vaporization temperatures, while small portable vaporizers allow you to vaporize marijuana wherever you are.


One of the healthier alternatives to smoking certainly includes consuming foods supplemented with cannabis or a drink containing cannabinoids. Today, abroad with the possibility of legal use of cannabis, you can see various biscuits, crackers, cakes as well as lemonades containing THC on the market. 

Even in our country, where the cultivation of cannabis with a THC content above 0.3% is not allowed, you can find alternatives to these products, which are only produced from technical cannabis. 

You can buy technical hemp products in the form of candies, biscuits, muffins, cakes in specialized stores. These products do not cause a psychoactive state and are rich in another healthy substance known as CBD.

Consumption of hemp oil

Hemp oil is made from whole hemp plants or hemp seeds, which can be conveniently taken orally in the form of capsules. These are usually gelatin capsules that you can consume directly or add to food or drinks. As with marijuana-based snacks, you need to be careful here, because the oils in the capsules can have really strong effects.


Tinctures are alcohol-based products containing cannabis that are applied orally directly under the tongue. Unlike oil consumed in capsules, the effects of ingested tincture appear immediately. 

This is because tincture substances immediately enter the bloodstream and we can then better control the effects and dosage of marijuana. Tinctures can be purchased and made at home according to your preferences with different flavors and with different THC or CBD content.


Cosmetic products containing cannabinoids such as creams, balms or shampoos are applied directly to the skin to relieve pain and inflammation in some conditions. 

The great advantage of cosmetics containing cannabis is its ability to treat and relieve the symptoms of the disease without a psychoactive effect. This is a great advantage for anyone who does not want to use cannabis internally.


Dabbing or vaporizing strong herbal concentrates is a way of consuming cannabis again without harmful smoke. It is a method where using a glass bong and a special dabbing cauldron, most often made of glass or metal, which is heated to certain temperatures. After heating a special cauldron, dab is slowly added, which spreads under the influence of heat, and we coat it in the form of dense steam.


In conclusion, no matter what method of smoking marijuana you choose, always be careful not to overestimate your options and always stay for a while to see the actual effects of marijuana and the effects on you. 

Now, thanks to our article, you already know that there are many methods of using cannabis without harmful combustion.…

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